Publications

Featured publications

Orcid files: https://orcid.org/0000-0002-6710-3798 

Mechanisms of Neuroimmunity in Neurodegenerative Diseases

Immunity in Alzheimer’s disease: From mechanisms to therapies.

Chen X, Holtzman D, Colonna M. 2026. Immunity. 1074-7613  Get PDF 

Dual orexin receptor antagonism with lemborexant enhances microglial clearance of β-amyloid in mice.

Sharma A, Segawa E, Chen X, Park S, Wang S, Irmen R, Constantino N, Wang C, Kanan M, Colonna M, Macauley S, Cheng J, Hatanaka K, Moline M, Musiek E. 2026. Mol Neurodegener, 21(1):28, PMID: 42174655  Get PDF 

Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.

Tabor G, Litvinchuk A, Chen Y, Allison A, Sun E, van Lengerich B, Davis S, West E, Schlachetzki J, Zeng C, Hu H, Lin P, Sharma P, Chen X, Parhizkar S, Song S, Bao X, Senthil L, Iyer A, You S, Holtzman D. 2026. Cell reports, 45(1), PMID: 116841  Get PDF 

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

Carling G, Fan L, Foxe N, Norman K, Wong M, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A, Ye P, Chen H, Huang Y, Amin S, Sereda R, Lopez-lee C, Zacharioudakis E, Chen X, Xu J, Cheng F, Gavathiotis E, Cuervo A, Holtzman D, Mok S, Sinha S, Sidoli S, Ratan R, Luo W, Gong S, Gan L. 2024. Neuron. 112. 1-20, PMID: 38328219   Get PDF 

Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.

AAIC, Kloske C, Tansey M, Wilcock D (Chen X, leading the study of Microglia-mediated T-cell infiltration and reactivity) 2024. Alzheimer’s and Dementia. PMID: 39692624  Get PDF 

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.

AAIC, Kloske C, Bu G, Goate A, Holtzman D (Chen X, leading the study of APOE and immune response in Alzheimer’s Disease) 2024. Alzheimer’s and Dementia. 20, 5815-6664, PMID: 39031528  Get PDF 

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.

Chen X, Firulyova M, Manis M, Herz J, Smirnov I, Aladyeva E, Wang C, Bao X, Finn M, Hu H, Shchukina I, Kim M, Yuede C, Kipnis J, Artyomov M, Ulrich J, Holtzman D. 2023. Nature. 615, 668-677, PMID: 36890231  Get PDF 

Emerging roles of innate and adaptive immunity in Alzheimer’s Disease.

Chen X, Holtzman D. 2022. Immunity. 55, 2236-2254, PMID: 36351425  Get PDF 

Mechanisms of Genetics and Epigenetics in Learning and Memory

Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning.

Chen X, Du Y, Broussard J, Kislin M, Yuede C, Zhang S, Dietmann S, Gabel H, Zhao G, Wang S, Zhang X, Bonni A. 2022.Nature. 605, 722-727, PMID: 35545673  Get PDF 

Robust principal component analysis for accurate outlier detection in RNA-Seq data.

Chen X, Zhang B, Wang T, Bonni A, Zhao G. 2020. BMC Bioinformatics. 21, 269. PMID: 32600248  Get PDF 

Transcriptional regulator SnoN promotes proliferation of cerebellar granule neuron precursors in the postnatal mouse brain.

Chen X, Chanda A, Ikeuchi Y, Zhang X, Goodman JV, Reddy NC, Majidi SP, Wu DY, Smith SE, Godec A, Oldenborg A, Gabel HW, Zhao G, Bonni S, Bonni A. 2019. J Neurosci. 39, 44-62. PMID: 30425119  Get PDF 

Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.

Smith SE, Chen X, Brier L, Bumstead J, Rensing N, Epstein A, Oldenborg A, Crowley J, Bice A, Dikranian K, Ippolito J, Haigis M, Papouin T, Zhao G, Wong M, Culver JP, Bonni A. 2020. Nature Communication. 11, 6164. PMID: 33268780  Get PDF 

Small molecule phenotypic screen identifies novel regulators of LDLR expression.

Krishnan N, Chen X, Donnelly-Roberts D, Mohler E.G, Holtzman D. M, Gopalakrishnan, S. M. 2020. ACS Chem Biol.15, 3262-3274. PMID: 33270420  Get PDF 

Immune and Metabolic Microenvironments Regulate Neurodevelopment and Neuronal Maturation

Graded and pan-neural disease phenotypes of Rett Syndrome linked with dosage of functional MeCP2.

Chen X*, Han X, Blanchi B, Guan W, Ge W, Yu YC*, Sun YE*. 2020. Protein Cell. 12, 639-652. PMID: 32851591 (co-corresponding author)   Get PDF 

Coupled electrophysiological recording and single cell transcriptome analyses revealed molecular mechanisms underlying neuronal maturation.

Chen X, Zhang K, Zhou L, Gao X, Wang J, Yao Y, He F, Luo Y, Yu Y, Li S, Cheng L, Sun YE. 2016. Protein Cell. 7, 175-186. PMID: 26883038 (Cover research)   Get PDF 

Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys.

Chen Y, Yu J, Niu Y, Qin D, Liu H, Li G, Hu Y, Wang J, Lu Y, Kang Y, Jiang Y, Wu K, Li S, Wei J, He J, Wang J, Liu X, Luo Y, Si C, Bai R, Zhang K, Liu J, Huang S, Chen Z, Wang S, Chen X, Bao X, Zhang Q, Li F, Geng R, Liang A, Shen D, Jiang T, Hu X, Ma Y, Ji W, Sun YE. 2017. Cell. 169, 945-955. PMID: 28525759   Get PDF 

TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys.

Liu H, Chen Y, Niu Y, Zhang K, Kang Y, Ge W, Liu X, Zhao E, Wang C, Lin S, Jing B, Si C, Lin Q, Chen X, Lin H, Pu X, Wang Y, Qin B, Wang F, Wang H, Si W, Zhou J, Tan T, Li T, Ji S, Xue Z, Luo Y, Cheng L, Zhou Q, Li S, Sun YE, Ji W. 2014. Cell Stem Cell. 14, 323-328. PMID: 24529597  Get PDF