2025-
Tenure-track Associate Professor and Principal Investigator in Institute for Immunology at Tsinghua University
IDG/McGovern Institute for Brain Research at Tsinghua University
Tsinghua-Peking Center for Life Sciences
Brain-immune communication in Alzheimer’s disease
2023-2025
Instructor in the lab of Dr. David Holtzman, Department of Neurology, Washington University, School of Medicine
Neuroimmunology and approaches for the treatment of Alzheimer’s disease
2019-2022
Postdoctoral fellow in the lab of Dr. David Holtzman, Department of Neurology, Washington University, School of Medicine
APOE and immune response in Alzheimer’s disease
2017-2019
Postdoctoral fellow in the lab of Dr. Azad Bonni, Department of Neuroscience, Washington University, School of Medicine
Genetic and epigenetic regulations in learning in adult mammalian brain
2009-2016
PhD dissertation
Departments of Immunology, Neuroscience, Tongji University, David Geffen School of Medicine, UCLA
Neuronal development and maturation
Dr. Xiaoying Chen is an Associate Professor and Principal Investigator at the Institute for Immunology and the IDG/McGovern Institute for Brain Research at Tsinghua University. She is also affiliated with the Tsinghua-Peking Center for Life Sciences.
Dr. Chen previously served as a faculty member in the Department of Neurology at the Hope Center for Neurological Disorders and the Knight Alzheimer’s Disease Research Center at Washington University School of Medicine. In 2025, she founded the System Neuroimmunology Laboratory at Tsinghua University. Her research focuses on understanding the brain-immune communication across health, aging, and disease. Interdisciplinary approaches including, single-cell multi-omics, metabolisms, clarity imaging, in vivo calcium imaging, optogenetics, and in vivo CRISPR gene editing, are applied in understanding the dialogue of brain-immune communication and developing potential therapeutic tools.
Dr. Xiaoying Chen has contributed significant insights into understanding neuronal plasticity during development (2017, Journal of Neuroscience; 2016, 2020, Protein & Cell; 2020 Nature Communication), learning activities (2022, Nature), and neuron-immune interactions in neurodegenerative disease (2022, 2025, Immunity; 2023, Nature). She has received a number of honors and awards, including the Jeffrey L. Morby Prize for Best Research in Alzheimer’s Disease from Cure Alzheimer’s Fund (2024), the Early Career Achievement Award from Alzheimer’s Association (2023), the Career Development Award from the Society for Neuroscience (2023), the Coins for Alzheimer’s Research Trust from Rotary Foundation (2023), the O’Leary Prize for Best Neuroscience Research at Washington University (2022), the Poletsky Award for Alzheimer’s Disease Research from Washington University (2022), and the Tau Consortium Fellowship from Rainwater Charitable Foundation (2019).
She is a member of Society for Neuroscience, Alzheimer’s Association, American Society for Neurochemistry, American Neurological Association and International Society for Molecular Neurodegeneration. Dr. Chen has reviewed papers for journals, including Immunity, Nature Neuroscience, Neuron, Alzheimer's & Dementia, Science Advances, Cell Reports, Molecular Neurodegeneration, and Journal of Clinical Investigation.
Zijing Zhou is a PhD student in the Peking-Tsinghua-NIBS (PTN) Joint Graduate Program at Tsinghua University, having joined Chen Lab in 2025. Her research focuses on the neuro-immune landscape of Alzheimer's Disease (AD). Specifically, she investigates the interactions of immune cells within the AD brain, with a particular emphasis on identifying AD-specific neoantigens and characterizing their cognate TCRs. In her free time, Zijing enjoys reading, travelling and petting dogs.
E-mail: zhou-zj25@mails.tsinghua.edu.cn
Qingwen Li is a graduate student in the the Chen Lab, at Tsinghua-Peking Center for Life Sciences (CLS) program. Her research focuses on understanding neuro-immune interaction in Alzheimer's disease. Outside the lab, Qingwen enjoys dancing.
E-mail: lqw25@mails.tsinghua.edu.cn
Zihui Wang is pursuing her Bachelor’s degree at Tsinghua University. With a strong background in imaging, she has been actively engaged in laboratory research focused on immune cell imaging in health and disease.
E-mail: wangzihu24@mails.tsinghua.edu.cn
Jiajia Li is a postdoctoral researcher in the Chen Lab. Her research focuses on neuroimmune interactions, with a particular interest in understanding how circadian rhythms regulate immune responses and neuronal plasticity in Alzheimer’s disease by classical systems neuroscience approaches. Outside the laboratory, Jiajia enjoys reading and cooking.
E-mail: ljj2844824369@163.com
Huiwen Qin obtained her Ph.D. from the Institute of Neuroscience, Chinese Academy of Sciences, where she studied microglia states across brain development. In the Chen Lab, she investigates neuro-immune interactions in neurodegenerative diseases. Outside the lab, Huiwen enjoys reading, painting, and cooking.
E-mail: hwqin@mail.tsinghua.edu.cn
Yanling Li is the laboratory technician in the Chen Lab at Tsinghua University. Her research focus centers on caring for the lab’s 'babies', the mice that support the group's scientific discoveries. She enjoys collaborating with colleagues and contributing to new technologies. Outside the lab, Yanling likes cooking.
E-mail: liyanling@mail.tsinghua.edu.cn
Lianzhang Wang is the senior lab manager in the Chen Lab at Tsinghua University. His research interest is decoding neural circuits involved in learning behavior. In the lab, he enjoys setting up equipment for systems neuroscience experiments and is committed to supporting the success of the next generation of scientists. Outside the lab, Lianzhang enjoys traveling.
E-mail: wanglianzhang@tsinghua.edu.cn